![]() One PT-ODF was chosen to represent the optimum formula according to the criteria of scoring the fastest DT and the highest Q 10. ![]() PT-ODFs were prepared via the solvent casting method and then evaluated. Methods: For the formulation and optimization of PT-ODFs, a 3 1.2 1 full factorial design was carried out, where the impact of polymer type and concentration on disintegration time (DT) and % PT released after 10 min (Q 10) was studied. ![]() Accordingly, this study aimed to formulate a bi-laminated oral disintegrating film (ODF) comprising PT in one layer and LN in the second one. Therefore, co-administration of statins with NSAIDs such as Lornoxicam (LN) could be a solution to the former problem. However, myalgia has been reported in hyperlipidemic patients receiving statins. Objective: Pitavastatin calcium (PT) is an innovative drug of statins that enhances HDL-C and lowers LDL-C. ![]() Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptÄepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Giza, EgyptÄ«i-laminated, Oral disintegrating film, Pitavastatin calcium, Lornoxicam, Bi-laminated Oral disintegrating film Pitavastatin calcium Lornoxicam Liquid Chromatography-Mass Spectrometry.
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